Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2
Jamie A. Kelly, Alexandra N. Olson, Krishna Neupane, Sneha Munshi, Josue San Emeterio, Lois Pollack, Michael T. Woodside, Jonathan D. Dinman
The paper compares the structural and functional conservation of -1 ribosomal frameshift signals between SARS-CoV and SARS-CoV-2, showing similar rates of frameshifting and the effectiveness of a small molecule inhibitor against SARS-CoV-2.
Journal of Biological Chemistry · Jun 22, 2020Peer-reviewedGenetics