Lois Pollack

Nucleotide-specific RNA conformations and dynamics within ribonucleoprotein condensates

This study uses X-ray scattering and simulations to analyze RNA conformational changes in RNP condensates, revealing sequence-specific dynamics and interactions with polybasic peptides.

Scaling and Merging Time-Resolved Laue Data with Variational Inference

This paper applies variational inference to time-resolved diffraction data of an enzyme to extract high signal-to-noise changes in electron density and evaluates hyperparameter impact.

Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron

This study uses mix-and-inject serial crystallography to resolve the catalytic mechanism of DJ-1, showing it catalyzes nearly two turnovers and reveals allosteric communication during glyoxalase activity.

Heterogeneity in the M. tuberculosis β-lactamase inhibition by Sulbactam

The paper uses MISC to study Sulbactam inhibition of M. tuberculosis BlaC, revealing heterogeneity, cooperativity, and conformational changes in atomic detail.

Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2

The paper compares the structural and functional conservation of -1 ribosomal frameshift signals between SARS-CoV and SARS-CoV-2, showing similar rates of frameshifting and the effectiveness of a small molecule inhibitor against SARS-CoV-2.