The SAMM50 rs3761472 causes mitochondrial dysfunction and metabolic dysfunction-associated steatotic liver disease
Su-Yeon Kim, Nahyun Kim, Uijin Kim, Young Jin Kim, Jun Ho Yun, Jiwon Heo, Hyunwoo Lee, Jiwon Choi, Inhae Jeong, Bong-Jo Kim, Ha Youn Shin
This study identifies SAMM50 rs3761472 as a risk factor for MASLD by showing it causes mitochondrial dysfunction and metabolic impairments in mice.
bioRxiv · Jun 4, 2025 · PreprintGenetics