An Organotypic Oral Squamous Cell Carcinoma Model Recapitulates Epithelial-Stromal Complexity at Single-cell Resolution and Reveals Matrix-derived Signalling as a Therapeutic Target.
Olga S. Yevlashevskaya, Joshua Z. Davies, Jiwon Choi, Shuai Yuan, Arsalan Latif, Gowsihan Poologasundarampillai, Deena M.A. Gendoo, Małgorzata Wiench
This paper develops an organotypic HNSCC model that captures epithelial-stromal complexity and identifies matrix-derived signals as therapeutic targets.
bioRxiv · Mar 12, 2026 · PreprintCancer Biology