Why do some predicted protein structures fold poorly? Benchmarking AlphaFold, ESMFold, and Boltz in maize
Olivia C. Haley, Laura E. Tibbs‐Cortes, Rita K. Hayford, Stephen F. Harding, Margaret Roth Woodhouse, Ethalinda K. S. Cannon, Jack M. Gardiner, John L. Portwood, Taner Z. Sen, Hye-Seon Kim, Carson M. Andorf
The paper benchmarks AlphaFold, ESMFold, and Boltz in maize to assess their performance on plant proteins, finding lower confidence scores and geometry issues in less conserved proteins.
bioRxiv · Jul 5, 2025 · PreprintBioinformatics