Prefusion conformation of SARS-CoV-2 receptor-binding domain favors interactions with human receptor ACE2
Nitesh Kumawat, Andrejs Tučs, Soumen Bera, Gennady N. Chuev, Marina V. Fedotova, Koji Tsuda, Sergey E. Kruchinin, Adnan Sljoka, Amit Chakraborty
The paper compares the conformational changes in SARS-CoV-2 and SARS-CoV-1 spike proteins' receptor-binding domains, showing how the prefusion conformation of SARS-CoV-2 enhances interactions with hACE2.
bioRxiv · Apr 22, 2021 · PreprintBioinformatics