Adnan Sljoka

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

Prefusion conformation of SARS-CoV-2 receptor-binding domain favors interactions with human receptor ACE2

The paper compares the conformational changes in SARS-CoV-2 and SARS-CoV-1 spike proteins' receptor-binding domains, showing how the prefusion conformation of SARS-CoV-2 enhances interactions with hACE2.

Allosteric regulation of Glutamate dehydrogenase deamination activity

This study identifies NADH as a positive allosteric modulator of GDH, revealing structural changes that inhibit deamination activity through conformational rearrangements.