Author

Michael J. Lyons

Greenwood Genetic CenterORCID 0000-0002-8644-5507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:zebrafish· 1

Frequent Co-Authors

Aleš MaveriD· 1 shared Alexandre ReymondiD· 1 shared Alfredo BruscoiD· 1 shared Andreas RumpiD· 1 shared Annabelle TuttleiD· 1 shared Barbara KlinkiD· 1 shared Binnaz YalciniD· 1 shared Chaofan ZhangiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Aleš MaverORCID

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2 papers

Recent·Most cited

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

Sissy Bassani, Jacqueline Chrast, Giovanna Ambrosini, Norine Voisin, Frédéric Schütz, Alfredo Brusco, Fabio Sirchia, Lydia Turban, Susanna Schubert, Rami Abou Jamra, Jan-Ulrich Schlump, Desiree DeMille, Pınar Bayrak‐Toydemir, Gary Rex Nelson, Kristen Nicole Wong, , Alexandre Reymond

The paper identifies variant-specific effects of AFF3 on transcriptome profiles through analysis of patient cohorts and zebrafish models, showing distinct pathophysiological mechanisms for different types of AFF3 variants.

medRxiv · Jan 14, 2024 · PreprintGenetic & Genomic Medicine

Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations

Sharissa L. Latham, Nadja Ehmke, Patrick Y. A. Reinke, Manuel H. Taft, Michael J. Lyons, Michael J. Friez, Jennifer A. Lee, Ramona Hecker, Michael Christoph Frühwald, Kerstin Becker, Teresa Neuhann, Denise Horn, Evelin Schröck, Katharina Sarnow, Konrad Grützmann, , Nataliya Di Donato

The paper reports a new clinical syndrome linked to ACTB mutations, characterized by thrombocytopenia, microcephaly, and developmental disability, and identifies altered cytoskeletal interactions in affected cells.

bioRxiv · Apr 18, 2018 · PreprintGenetics