Patrick Y. A. Reinke

The paper uses statistical crystallography to model correlated motions in SARS-CoV-2 Mpro and shows how dimerization affects catalytic activity through structural links.

This study shows that selecting the correct crystal form significantly improves hit rates in crystallographic fragment screening for drug discovery.

The paper reports a new clinical syndrome linked to ACTB mutations, characterized by thrombocytopenia, microcephaly, and developmental disability, and identifies altered cytoskeletal interactions in affected cells.