Long-read genome sequencing and multi-omics in aging and neurodegeneration
Tanner D. Jensen, Yann Le Guen, Lia Talozzi, Sherry Yang, John E. Gorzynski, Andrés Peña‐Tauber, Ilaria Stewart, Alexis Ferrasse, Daniel C. Nachun, Taylor M. Maurer, Justin Lee, Rafael Catoia Pulgrossi, Jun Young Park, Jingyu Zhang, Anthony D. Wagner, , Michael D. Greicius
The paper uses long-read genome sequencing and multi-omics data to identify structural variants associated with aging and neurodegenerative diseases, finding that SVs are more likely to be causal than SNVs.
medRxiv · Oct 10, 2025 · PreprintGenetic & Genomic Medicine