Nonlinear Mixed-Effects and Full Bayesian Population Pharmacokinetic Analysis of Ceftolozane-Tazobactam in Critically Ill Patients
Paulina Okuńska, Michał Borys, Elżbieta Rypulak, Paweł Piwowarczyk, Marta Szczukocka, Grzegorz Raszewski, Mirosław Czuczwar, Paweł Wiczling
This study compares nonlinear mixed-effects and Bayesian hierarchical models for pharmacokinetics of ceftolozane-tazobactam in critically ill patients, showing that Bayesian methods improve parameter consistency with literature when prior information is included.
bioRxiv · Mar 26, 2026 · PreprintPharmacology & Toxicology