Title: Engineering Plasmids with Synthetic Origins of Replication
Baiyang Liu, Zhi Ren Darren Seet, Xiao P. Peng, Matthew R. Bennett, Matthew R. Lakin, James Chappell
The paper designs synthetic origins of replication (SynORI) that allow customizable and modular plasmid copy numbers and environmental signal responses in E. coli.
Nature Communications · Feb 2, 2026Peer-reviewedSynthetic Biology