Quantitative omnigenic model discovers interpretable genome-wide associations
Natália Ružičková, Michal Hledík, Gašper Tkačik
The paper introduces the quantitative omnigenic model (QOM) to improve GWAS interpretability by integrating regulatory network knowledge, showing it can predict gene expression with fewer parameters and extract causal effect chains.
Proceedings of the National Academy of Sciences · Oct 23, 2024Peer-reviewedGenomics