BioinformaticsbioRxivPreprint
A knowledge-guided approach to recovering important rare signals from high-dimensional single-cell data
Zhenghao Zhang, Jiamin Chen, Haoran Wu…·Kevin Yuk-Lap Yip
This paper introduces a framework that guides dimensionality reduction using knowledge-derived genes to recover rare but important signals in single-cell data, demonstrating its effectiveness in identifying rare cell subtypes.