Kelly Yichen Li

This paper introduces a measure of transcriptional dyscoordination to quantify aging in single cells, showing it increases with age and is linked to cellular processes like senescence and genome instability.

This study evaluates how large language models perform in-class learning for antibody classification using biological sequences, finding that few-shot prompting with diverse demonstrations achieves competitive results.

This paper introduces a framework that guides dimensionality reduction using knowledge-derived genes to recover rare but important signals in single-cell data, demonstrating its effectiveness in identifying rare cell subtypes.

The paper investigates how three-dimensional chromatin domain structures influence gene regulation and finds that domain surfaces are enriched for regulatory elements and disease variants.