Sequence and supercoiling-dependent effects on the structural dynamics of DNA minicircles
Manuel Micheloni, Luca Tubiana, Raffaello Potestio, Lorenzo Petrolli
The paper uses molecular dynamics simulations to study how DNA sequence and superhelical density affect structural dynamics in minicircles, finding that undercoiling leads to stable denaturation bubbles.
Biophysical Reports · Oct 31, 2025Peer-reviewedBiophysics