Author

Ruben H.P. Vorderman

Leiden University Medical CenterORCID 0000-0002-8813-1528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metagenomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Hailiang MeiiD· 2 shared Aloys C.M. KroesiD· 1 shared Andrew Green· 1 shared Anneloes L. van Rijn-Klink· 1 shared Annelore Van Der KeleniD· 1 shared Ashwin Ramdien· 1 shared Carli M. Tops· 1 shared Claire PallesiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Hailiang MeiORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineHuman Genetics and Genomics AdvancesPeer-reviewedJul 18, 2025

Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9

Noah C. Helderman, Ting Yang, Claire Palles…·Margot Julia Wyrwoll

This study identifies biallelic germline variants in MCM8 and MCM9 as linked to polyposis, gastric cancer, early-onset colorectal cancer, and hypogonadism, with MCM9 variants showing stronger associations.

3 citations

humanwhole-exome sequencing

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MicrobiologybioRxivPreprintDec 10, 2018

METAGENOMIC SEQUENCING FOR COMBINED DETECTION OF RNA AND DNA VIRUSES IN RESPIRATORY SAMPLES FROM PAEDIATRIC PATIENTS

Sander van Boheemen, Anneloes L. van Rijn-Klink, Nikos Pappas…·Jutte de Vries

This study evaluates an in-house mNGS protocol for detecting RNA and DNA viruses in pediatric respiratory samples, showing high concordance with PCR and identifying additional pathogens not detected by routine methods.

DOI 10.1101/492835

humanmetagenomics

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