Age-related sensory dysfunction reconfigures the spinal circuitry for touch, itch and pain
David G. Acton, Sofia Pimpinella, Martyn Goulding
This study shows that aging-related loss of touch receptor signaling leads to spinal circuit degeneration, causing itch and pain hypersensitivity in mice.
bioRxiv · Dec 22, 2025 · PreprintNeuroscience