Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets
Nina R. Derby, Brooke I. Johnson, Sreya Biswas, Miranda B. Fischer, Katherine A. Fancher, Cristina Luevano-Santos, Sofiya Yusova, Kimberly A. Meyer, Yohannes M. Abraham, Savannah S. Lutz, Cole Fisher, Maria Cristina Pacheco, Jeremy V Smedley, Benjamin J. Burwitz, Donald L. Sodora
The paper examines MX1 expression in liver macrophage subsets during SIV infection and identifies Kupffer cells as the primary source of MX1, which may contribute to liver inflammation in HIV.
PLoS Pathogens · Sep 26, 2025Peer-reviewedImmunology