Evolutionarily Conserved Amyloid Aggregation in the PACAP Peptide Family Is Controlled by Heparin-Sensitive Lys/Arg Gatekeeper Residues
Dániel Horváth, Szebasztián Szaniszló, Zsolt Dürvanger, Zsolt Fazekas, Yen Kim Hoang Doung, András Perczel
The paper shows that amyloid formation in PACAP-family peptides is controlled by heparin-sensitive lysine/arginine residues, conserved across evolution despite sequence divergence.
bioRxiv · May 7, 2026 · PreprintBiochemistry