Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy
Jennifer OʼBrien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristián, Rajeshwari Chellappan, Samuel Rubin, Ashley L. Kiemen, Catherine Pei-Ju Lu, , Cheng‐Ying Ho
This study shows that SIRT1 and BDNF in skin keratinocytes reduce mechanical allodynia in diabetic neuropathy by maintaining Meissner corpuscle innervation.
Brain · Mar 27, 2024Peer-reviewedNeuroscience