Koping Chang

This study shows that LINE1 RNA dysregulation impairs chromatin accessibility in ALS/FTD, leading to transcriptional changes and neuronal dysfunction.

This study shows that elevated nuclear TDP-43 causes species-specific exon skipping, which differs from exon skipping seen in TDP-43 loss-of-function, highlighting the need for careful interpretation of TDP-43 overexpression models.

This study uses MD-MRI to map cortical astrogliosis and distinguishes cognitive resilience from dementia in Alzheimer's disease despite significant neuropathology.

This study shows that SIRT1 and BDNF in skin keratinocytes reduce mechanical allodynia in diabetic neuropathy by maintaining Meissner corpuscle innervation.