The strictly conserved GGG-tracts in the 5' and 3' long terminal repeat of HIV-1 are critical to control multiple steps of HIV-1 replication to prevent acquisition of unwanted mutations in the region
Takeshi Yoshida, Yuho Kasuya, Tetsuro Matano, Takao Masuda, Hiroyuki Yamamoto
This study shows that conserved GGG-tracts in HIV-1 LTRs are essential for accurate RNA transcription, packaging, and reverse-transcription to prevent mutations in the LTR region.
bioRxiv · Apr 26, 2026 · PreprintMicrobiology