Jacqueline Cherfils

The paper maps a bidirectional allosteric pathway in Arf GTPases that controls access to a functional molten globule state through the GDP ligand, rather than directly affecting switching rates.

This study shows that the N-terminal helix of Arf1 stabilizes the repressed state by globally stabilizing the native structure, rather than through specific interactions with the switch region.

The paper identifies a mutation in Cdc42 that causes a severe autoinflammatory syndrome by trapping the protein in the Golgi and disrupting its membrane interaction.