The mechanisms of gene regulatory networks constrain evolution: A lesson from synthetic circuits
Yolanda Schaerli, Alba Jiménez, José M. Duarte, Ljiljana Mihajlovic, Julien Renggli, Mark Isalan, James A. Sharpe, Andreas Wagner
The paper shows that different gene regulatory networks in E. coli constrain phenotypic variation differently, even when producing the same phenotype.
Molecular Systems Biology · Sep 1, 2018Peer-reviewedSystems Biology