Bone mechano-response is driven by locomotion transitions during vertebrate evolution
Saeka Shimochi, Clara Brunet, Margalida Fontcuberta-Rigo, Katja Hrovat, Pere Puigbò, Miho Nakamura
This study identifies non-collagenous bone matrix proteins as regulators of bone mechano-response, showing evolutionary transitions in locomotion shaped their roles in humans.
Communications Biology · Nov 29, 2025Peer-reviewedEvolutionary Biology