This study uses Mendelian randomization to identify risk factors for kidney function decline in CKD and the general population, finding causal effects of type-2 diabetes and high TSH.

medRxiv · Sep 8, 2026 · PreprintGenetic & Genomic Medicine

Cardiometabolic drugs and kidney function - a drug target Mendelian randomisation study

Aristomo Andries, Schyler Marie Bennett, Venexia M. Walker, Iris M. Heid, Anna Köttgen, Mathias Gorski, Artemis A. Briasouli, Jie Zheng, Kristian Hveem, Stein Ivar Hallan, Bjørn Olav Åsvold, Tom R. Gaunt, Ben Michael Brumpton, Humaira Rasheed

This study uses Mendelian randomization to assess how cardiometabolic drugs affect kidney function, finding specific drug targets influence eGFR and related biomarkers.

medRxiv · Jun 16, 2025 · PreprintGenetic & Genomic Medicine

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Kira J. Stanzick, Yong Li, Pascal Schlosser, Mathias Gorski, Matthias Wuttke, Laurent F. Thomas, Humaira Rasheed, Bryce X. Rowan, Sarah E. Graham, Brett R. Vanderweff, Snehal B. Patil, VA Million Veteran Program, Cassianne Robinson‐Cohen, J. Michael Gaziano, Christopher J. O’Donnell, , Thomas W. Winkler

This study identifies 424 new loci associated with kidney function using GWAS data from over 1.2 million individuals and prioritizes 34 genes for further functional investigation.

Nature Communications · Jul 16, 2021Peer-reviewedGenetics

Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis

Sarah E. Graham, Jonas Bille Nielsen, Matthew Zawistowski, Wei Zhou, Lars G. Fritsche, Maiken Elvestad Gabrielsen, Anne Heidi Skogholt, Ida L. Surakka, Whitney Hornsby, Damian Fermin, Daniel B. Larach, Sachin Kheterpal, Chad M. Brummett, Seunggeun Lee, Hyun Min Kang, , Cristen J. Willer

This study identifies 147 genetic loci associated with eGFR, including 53 novel ones, and finds sex-specific effects on kidney function.

Nature Communications · Apr 23, 2019Peer-reviewedGenomics