Anti-Melanoma Differentiation-Associated protein 5 Auto-Antibodies Promote a Profibrotic Phenotype in a Human Lung Fibroblast Cell Line
Silvia Calandra, Maristella Maggi, Andrea Previtali, Luisa Iamele, Paola Cipriani, Luca Navarini, Roberto Giacomelli, Piero Ruscitti, Veronica Codullo, Giovanni Zanframundo, Claudia Scotti, Lorenzo Cavagna
This study shows that anti-MDA5 autoantibodies and MDA5 form a complex that promotes fibroblast proliferation and pro-fibrotic responses in lung fibroblasts, contributing to interstitial lung disease.
bioRxiv · Jun 1, 2026 · PreprintImmunology