Ligands with poly-fluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities
Sharif Md Anisuzzaman, Ivan M. Geraskin, Müslüm İlgü, Lee Bendickson, George A. Kraus, Marit Nilsen‐Hamilton
The paper investigates how poly-fluorophenyl-modified ligands alter the structural dynamics of Spinach2 and Broccoli aptamers, increasing ligand affinity through a slow structural rearrangement.
RNA · Mar 29, 2022Peer-reviewedMolecular Biology