Huntingtin CAG repeat is a continuous modifier of brain structure and health vulnerability
Harriet Cullen, Christopher Clarkson, Henrique Nascimento, Matteo Zanovello, Jeffrey Long, Mark J. Caulfield, Michael A. Simpson, Sarah J. Tabrizi, Arianna Tucci
This study shows that HTT CAG repeat length within the normal and intermediate range is associated with brain structure and neuropsychiatric risk, challenging the view of CAG repeats as purely categorical.
medRxiv · May 12, 2026 · PreprintGenetic & Genomic Medicine