Christopher T. Clarkson

Huntingtin CAG repeat is a continuous modifier of brain structure and health vulnerability

This study shows that HTT CAG repeat length within the normal and intermediate range is associated with brain structure and neuropsychiatric risk, challenging the view of CAG repeats as purely categorical.

Increased frequency of repeat expansion mutations across different populations

The paper estimates the frequency of repeat expansion mutations across populations using whole genome sequencing data and finds higher expected prevalence than current reports.

Nucleosome reorganisation in breast cancer tissues

This study identifies patient-specific and common nucleosome repositioning patterns in breast cancer tissues and links them to cancer pathways and liquid biopsy applications.

Nucleosome repositioning in chronic lymphocytic leukaemia

This study identifies changes in nucleosome positioning and packing in chronic lymphocytic leukaemia, linking them to epigenetic mechanisms and patient stratification.

DNA sequence-dependent formation of heterochromatin nanodomains

The paper develops a chromatin hierarchical lattice framework to predict heterochromatin nanodomains and identifies DNA sequence and protein binding factors that determine their formation and boundaries.

CTCF-dependent chromatin boundaries formed by asymmetric nucleosome arrays with decreased linker length

The paper investigates how CTCF binding influences chromatin boundaries through asymmetric nucleosome arrays and NRL changes in mouse cells.

Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells

The paper investigates how PARylation of CTCF affects its chromatin binding and gene expression in breast cells during cell cycle arrest.