Christina E. Hugenschmidt

Insulin resistance, cognition, and functional brain network topology in older adults with obesity

This study examines how peripheral and neuronal insulin resistance relate to executive function and brain network topology in older adults with obesity, finding that peripheral IR negatively affects executive function and hippocampal network topology.

Resting-state connectivity modifies the effects of amyloid on cognitive and physical function: evidence for network-based cognitive reserve

The paper examines how resting-state brain networks modify the relationship between amyloid beta and cognitive/physical function in older adults, suggesting brain networks as a buffer against amyloid's negative effects.

Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

The paper identifies increased connectivity between sensorimotor cortex and anterior cingulate cortex as a marker of physical resilience in older adults with high white matter hyperintensity volumes.