Shannon L. Macauley

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

This study investigates how tau pathology affects metabolism and excitatory activity in mouse models, finding that it preserves glucose tolerance and shifts metabolic flux toward glutamate synthesis.

Insulin resistance, cognition, and functional brain network topology in older adults with obesity

This study examines how peripheral and neuronal insulin resistance relate to executive function and brain network topology in older adults with obesity, finding that peripheral IR negatively affects executive function and hippocampal network topology.

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease

This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.

Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementia

This study shows that a mutation in the MAPT gene disrupts autophagy in neurons, leading to Tau accumulation, and that an autophagy enhancer drug reduces Tau levels.

A unique multi-synaptic mechanism regulates dopamine release in the nucleus accumbens during adolescence

The paper investigates differences in dopamine release regulation in adolescent versus adult rats, identifying a unique multisynaptic mechanism involving acetylcholine and nicotinic receptors.

Kir6.2-KATP channels alter glycolytic flux to modulate cortical activity, arousal, and sleep-wake homeostasis

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV-ISF) reveals sex-dependent changes in microglial EV proteome in response to Aβ pathology

The paper develops a method to collect hippocampal interstitial fluid extracellular vesicles (EVISF) and finds sex-dependent changes in microglial EV proteome related to Aβ pathology.

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

This study shows chronic ethanol exposure worsens Alzheimer's-like pathology, behavior, and metabolism in APP/PS1 mice by increasing amyloid plaques, altering brain metabolism, and affecting behavior.

Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

Kir6.2-containing KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology

This study shows that Kir6.2-KATP channels are necessary for hyperglycemia-induced increases in amyloid-beta and Alzheimer's pathology by regulating lactate transport and Aβ release.

Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.

Type-2-diabetes alters CSF but not plasma metabolomic and AD risk profiles in vervet monkeys

This study shows that type 2 diabetes in vervet monkeys alters cerebrospinal fluid metabolites and amyloid levels, but not plasma metabolites or AD risk profiles.