Compositional data modeling of high-dimensional single cell RNA-seq (CoDA-hd): its advantages over commonly used normalization approaches
Jinghan Huang, Sheung Chi Phillip Yam, KS Leung…·Nelson L.S. Tang
This paper introduces CoDA-hd, a compositional data analysis approach for scRNA-seq, showing its advantages in dimension reduction, clustering, and trajectory inference compared to log-normalization.