Single cell Correlation Analysis (SCA): Identifying self-renewing subpopulation of human acute myeloid leukemia stem cells using single cell RNA sequencing analysis
Yoonkyu Lee, Wen Wang, Timothy K. Starr, Klara E. Noble-Orcutt, Chad L. Myers, Zohar Sachs
This paper introduces SCA, a computational method for identifying rare LSC populations in AML using scRNA-seq, and finds a conserved self-renewal program associated with poor prognosis.
bioRxiv · Mar 2, 2026 · PreprintCancer Biology