Yoonkyu Lee

This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.

This paper introduces SCA, a computational method for identifying rare LSC populations in AML using scRNA-seq, and finds a conserved self-renewal program associated with poor prognosis.

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

This study evaluates dimensionality reduction methods to normalize CRISPR screen data and improve functional gene network extraction from the DepMap.