Learning the native-like codons with a 5'UTR and RNA secondary structure aided species-informed transformer model
Qiuyue Hu, Xiaolin Tian, Yuanning Li, Rui Zhou, Zhihao Wang, Jintao Meng, Shen Wang, Jingjing Guo, Weifeng Li, Liangzhen Zheng, Yanjie Wei
TransCodon is a Transformer-based model that predicts optimal synonymous codons by integrating species-specific information, 5'UTRs, and RNA structure, improving translational efficiency in heterologous hosts.
bioRxiv · Jul 19, 2025 · PreprintBioinformatics