Rui Zhou

Learning the native-like codons with a 5'UTR and RNA secondary structure aided species-informed transformer model

TransCodon is a Transformer-based model that predicts optimal synonymous codons by integrating species-specific information, 5'UTRs, and RNA structure, improving translational efficiency in heterologous hosts.

Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

This study shows that Alzheimer's mutations stabilize harmful enzyme-substrate complexes in gamma-secretase, leading to synaptic loss rather than the released Aβ peptides being the primary cause.

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

The paper presents cryo-EM structures of the GABAB receptor in inactive and active states, revealing structural changes and Gi1 coupling mechanisms.