The paper updates and expands the MDSGene database with clinical and genetic data on LRRK2 variants in Parkinson's disease, including 7,885 individuals and 292 variants.

medRxiv · Dec 10, 2024 · PreprintGenetic & Genomic Medicine

Investigating the Contribution of White Matter Hyperintensities and Cortical Thickness to Empathy in Neurodegenerative and Cerebrovascular Diseases

Miracle Ozzoude, Brenda Maricela Varriano, Derek Beaton, Joel Ramirez, Melissa F. Holmes, Christopher J.M. Scott, Fuqiang Gao, Kelly M. Sunderland, Paula M. McLaughlin, Jennifer S. Rabin, Maged Goubran, Donna T. Kwan, Angela Roberts, Robert Bartha, Sean P. Symons, , Angela K. Troyer

This study examines the relationship between white matter hyperintensities, cortical thickness, and empathy in neurodegenerative and cerebrovascular diseases, finding associations with specific brain regions and demographic factors.

GeroScience · Mar 16, 2022Peer-reviewedNeuroscience

Genome-wide association studies of LRRK2 modifiers of Parkinson's disease

Dongbing Lai, Babak Alipanahi, Pierre Fontanillas, Tae-Hwi Linus Schwantes-An, Jan Olav Aasly, Roy N. Alcalay, Gary W. Beecham, Daniela Berg, Susan Bressman, Alexis Brice, Kathrin Brockmann, Lorraine N. Clark, Mark Cookson, Sayantan Das, Vivianna M. Van Deerlin, , Tatiana Foroud

This study identifies genetic modifiers of LRRK2 mutations in Parkinson's disease, finding a significant variant in CORO1C and a polygenic risk score effect on penetrance.

Annals of Neurology · May 3, 2021Peer-reviewedGenetic & Genomic Medicine