Author

Saúl Herranz-Martín

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-9239-2704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Ahad A. RahimiD· 1 shared Alexander J. SmithiD· 1 shared Amna Z. ShahiD· 1 shared Andrés Vicente-AcostaiD· 1 shared Frida LoríaiD· 1 shared Giulia MassaroiD· 1 shared Izabela P. KlaskaiD· 1 shared Javier Díaz‐NidoiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Ahad A. RahimORCID

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2 papers

Recent·Most cited

Glial cell activation precedes neurodegeneration in the cerebellar cortex of the YG8-800 murine model of Friedreich's ataxia

Andrés Vicente-Acosta, Saúl Herranz-Martín, María Ruth Pazos, Jorge Galán-Cruz, Mario Amores, Frida Loría, Javier Díaz‐Nido

The paper characterizes the progression of cerebellar degeneration in a humanized mouse model of Friedreich's ataxia, showing early glial activation precedes neuronal loss.

bioRxiv · May 17, 2024 · PreprintNeuroscience

Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease

Sophia-Martha kleine Holthaus, Saúl Herranz-Martín, Giulia Massaro, Mikel Aristorena, Justin Hoke, Michael P. Hughes, Ryea N. Maswood, Olha Semenyuk, Mark Basche, Amna Z. Shah, Izabela P. Klaska, Alexander J. Smith, Sara Mole, Ahad A. Rahim, Robin R. Ali

This study shows that neonatal brain-directed gene therapy using AAV9-CLN6 significantly improves survival, motor function, and reduces neuropathology in a mouse model of CLN6 Batten disease.

Human Molecular Genetics · Aug 28, 2019Peer-reviewedNeuroscience