Development of a cellular reporter assay to measure activity of MutSβ, a therapeutic target for Huntington's disease
Jian An, Theresa Towle, Melis A. Aksit, Mohiuddin Mohiuddin, Samantha Castaneda, Reiko Nakashima, Rob Moccia, Christine Bulawa, James Fleming
The paper develops a cellular reporter assay to measure MutSβ activity and shows its modulation by MSH3 levels and HDAC3 inhibitors.
bioRxiv · Sep 7, 2023 · PreprintNeuroscience