This paper analyzes genomic epidemiology and antifungal resistance in Candida auris isolates from Colombia, identifying genetic clusters and resistance mechanisms.

mSphere · Feb 1, 2024Peer-reviewedGenomics

Chromosomal rearrangements and loss of subtelomeric adhesins linked to clade-specific phenotypes in Candida auris

José Fernando Muñoz, Rory M. Welsh, Terrance Shea, Dhwani Govil Batra, Lalitha Gade, Dakota T. Howard, Lori A. Rowe, Jacques F. G. M. Meis, Anastasia P. Litvintseva, Christina A. Cuomo

The paper identifies chromosomal rearrangements and loss of subtelomeric adhesins in Clade II of Candida auris, linking these to reduced virulence and outbreak potential compared to other clades.

Genetics · Feb 24, 2021Peer-reviewedGenomics

Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses

Nancy A. Chow, José Fernando Muñoz, Lalitha Gade, Elizabeth L. Berkow, Li Xiao, Rory M. Welsh, Kaitlin Forsberg, Shawn R. Lockhart, Rodney D. Adam, Alexandre Alanio, Ana Alastruey‐Izquierdo, Sahar Althawadi, Ana Belén Araúz, Ronen Ben‐Ami, Amrita Bharat, , Christina A. Cuomo

This study traces the global emergence and evolutionary history of Candida auris using population genomic analyses of isolates from 19 countries, identifying clades, phylogeographic patterns, and antifungal resistance mechanisms.

mBio · Apr 27, 2020Peer-reviewedGenomics

Genomic basis of multidrug-resistance, mating, and virulence in Candida auris and related emerging species

José Fernando Muñoz, Lalitha Gade, Nancy A. Chow, Vladimir N. Loparev, Phalasy Juieng, Elizabeth L. Berkow, Rhys A. Farrer, Anastasia P. Litvintseva, Christina A. Cuomo

The paper analyzes genome assemblies and RNA-Seq data from Candida auris and related species to identify genomic features associated with drug resistance, mating potential, and virulence.

Nature Communications · Dec 11, 2018Peer-reviewedGenomics