Protein-protein interaction priors shape biologically coherent latent spaces for causally concordant cross-omic translation
David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Rebecka J. Jörnsten, Mika Gustafsson
This paper introduces a PPI prior to guide autoencoder embeddings, improving biological coherence and downstream task performance in multi-omic data.
bioRxiv · Oct 13, 2025 · PreprintBioinformatics