Muller’s ratchet as a mechanism of frailty and multimorbidity
Diddahally R. Govindaraju, Hideki Innan
This paper models mutation accumulation in cell populations using the Moran process, showing how Muller’s ratchet explains cellular senescence, frailty, and multimorbidity through mutation load and age-related effects.
bioRxiv · Oct 10, 2018 · PreprintGenetics