Hideki Innan

Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements

The paper develops a mathematical model to analyze the evolutionary dynamics of piRNA and KZFP defense systems against transposable elements, showing how they can coexist through distinct suppression mechanisms.

Spontaneous Emergence and Turnover of the Sex-Determining Locus

This study develops an evolutionary model showing how disruptive selection can lead to the spontaneous emergence of a sex-determining locus and sexual differentiation through gene regulatory networks.

High-performance pipeline for MutMap and QTL-seq

The paper introduces updated pipelines for MutMap and QTL-seq that are faster, easier to use, and more accessible via bioconda.

Muller’s ratchet as a mechanism of frailty and multimorbidity

This paper models mutation accumulation in cell populations using the Moran process, showing how Muller’s ratchet explains cellular senescence, frailty, and multimorbidity through mutation load and age-related effects.