Author

James R. Brown

Drexel UniversityORCID 0000-0002-9368-627XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

James R. Brown1 paper · GlaxoSmithKline (United States)

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:contrastive learning· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Bahrad Ali SokhansanjiD· 1 shared GAIL L. ROSENiD· 1 shared Hai-Feng JiiD· 1 shared Hyunwoo YooiD· 1 shared Milad Amir ToutounchianiD· 1 shared Mohammad S. RefahiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioinformatics

Bahrad Ali SokhansanjORCID

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1 paper

Recent·Most cited

Nevermore: Target-Conditioned Protein-Ligand Representation Learning for Multi-Objective Lead Optimization with Database-Grounded Retrieval

Mohammad S. Refahi, Milad Amir Toutounchian, Bahrad Ali Sokhansanj, Hyunwoo Yoo, James R. Brown, Hai-Feng Ji, GAIL L. ROSEN

Nevermore improves lead optimization by balancing binding affinity and developability constraints using a database-grounded framework with interpretable molecular edits.

Biology · Jun 21, 2026Peer-reviewedBioinformatics