Alexander Rauch

Glucocorticoid signalling exerts distinct lineage-permissive and dose-dependent disruptive actions during human osteoblast differentiation

This study investigates how glucocorticoid signaling affects human osteoblast differentiation at different doses and contexts, revealing distinct mechanisms for lineage-permissive and disruptive effects.

Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro

This study shows that stromal cells with lineage-specific gene programs are more prone to adopt opposing phenotypes, supporting coordinated trans-differentiation between osteoblasts and adipocytes.

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities

This study identifies genetic subtypes of obesity that uncouple adiposity from cardiometabolic risks, revealing distinct biological pathways and protein associations.