Susanne Mandrup

This study shows that intraoperative dexamethasone significantly alters hepatic gene expression in biopsy samples, confounding transcriptomic analyses of liver tissue.

This study investigates how glucocorticoid signaling affects human osteoblast differentiation at different doses and contexts, revealing distinct mechanisms for lineage-permissive and disruptive effects.

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study examines transcriptional changes in human adipose tissue during weight loss from lifestyle and bariatric surgery, showing significant remodeling and reduced inflammation.

This study shows that ACBP is not essential for adipose tissue function or systemic energy metabolism in mice, as knockout mice show no significant metabolic changes.

The paper links adipose tissue cell states to progression and clinical subtypes of MASLD in human obesity using single-nucleus RNA sequencing and bulk RNA-seq data.

The paper uses single nucleus multiomics to study early inflammatory responses in mouse pancreatic islets under high-fat diet, finding proinflammatory gene activation and reduced beta-cell identity.

This study identifies protein biomarkers for MASLD using proteomics data from liver, blood, and adipose tissue, showing improved prediction models over existing methods.

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

This study examines the transcriptomic responses of two sponge species and their microbial symbionts to seasonal anoxia and hypoxia, revealing species-specific adaptations and limited metabolic changes under low oxygen conditions.

This paper shows that the gliopeptide ODN, when administered after day 3 post-stroke, improves motor recovery in mice by correcting cortical excitability.

This study shows that a compromised epidermal barrier increases energy expenditure, food intake, and white adipose tissue browning while preventing diet-induced obesity.

This study shows that loss of TLE3 enhances mitochondrial function in beige adipocytes, improves glucose metabolism, and prevents weight gain.