Author

Luca De Stefano

National Research CouncilORCID 0000-0002-9442-4175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessia AmetranoiD· 1 shared Bruno MirandaiD· 1 shared Maria Rosaria CosciaiD· 1 shared Principia DardanoiD· 1 shared Rosalba MorettaiD· 1 shared Umberto OresteiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperMolecular Biology

Alessia AmetranoORCID

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1 paper

Recent·Most cited

Investigations on Antarctic fish IgM drives the generation of an engineered mAb by CRISPR/Cas9

Alessia Ametrano, Bruno Miranda, Rosalba Moretta, Principia Dardano, Luca De Stefano, Umberto Oreste, Maria Rosaria Coscia

This study uses CRISPR/Cas9 to engineer a monoclonal antibody by replacing its hinge region with that of Antarctic fish IgM, resulting in a 2.5-fold higher affinity for the antigen.

bioRxiv · Oct 4, 2023 · PreprintMolecular Biology