This paper decomposes the genetic background of chronic back pain into shared and unshared components, identifying genes associated with different subphenotypes and biological pathways.

Human Molecular Genetics · Dec 16, 2024Peer-reviewedGenetic & Genomic Medicine

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain at different anatomic sites

Yakov A. Tsepilov, Maxim B. Freidin, Alexandra S. Shadrina, Sodbo Sharapov, Elizaveta E. Elgaeva, Jan H. M Van Zundert, Lennart C. Karssen, Pradeep Suri, Frances M. K. Williams, Yurii S. Aulchenko

The paper identifies shared genetic factors for chronic musculoskeletal pain across different anatomic sites using genetically independent phenotypes derived from UK Biobank data.

Communications Biology · Jun 25, 2020Peer-reviewedGenomics

Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals

Maxim B. Freidin, Yakov A. Tsepilov, Melody R. Palmer, Lennart C. Karssen, CHARGE Musculoskeletal Working Group, Pradeep Suri, Yurii S. Aulchenko, Frances M. K. Williams

This study conducts a large GWAS on back pain, identifies genetic loci, and explores genetic correlations with risk factors, revealing complex genetic architecture and molecular pathways.

Pain · Feb 6, 2019Peer-reviewedGenetics

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

Pradeep Suri, Melody R. Palmer, Yakov A. Tsepilov, Maxim B. Freidin, Cindy Germaine Boer, Michelle S. Yau, Daniel S. Evans, Andrea Gelemanović, Traci M. Bartz, Maria Nethander, Liubov S Arbeeva, Lennart C. Karssen, Tuhina Neogi, Archie I Campbell, Dan Mellström, , Frances M. K. Williams

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.

PLoS Genetics · Sep 27, 2018Peer-reviewedGenomics